![]() 5 Instead, they used a monolayer method which resulted in the obtaining of the RPE cells 40 days later, a timeframe in line with human fetal RPE cell development. ![]() The researchers’ strategy for differentiating the RPE cells is unique as other protocols that have been recorded have used the embryoid body differentiation method to get the RPE from embryonic stem cells. These stem cells are further differentiated to generate RPE (iRPE) monolayer cells. In this study, the cells were taken from normal subjects as well as from patients with OCA1A and OCA2 and they were then reprogrammed into iPSCs. Thus, the researchers wanted to study the abnormalities during the genesis of melanosomes and melanins in the RPE of patients with OCA as they think the RPE plays a crucial role during the formation of the melanosomes. However, there has been no degenerative effects seen in the RPE of OCA patients, despite the role of melanosomes which are melanin-containing organelles responsible for the pigmentation of mammalian hair and skin. The RPE of individuals with OCA lack pigments and suffer from defects in their foveal development which leads to reduced visual acuity, especially in the area of their central vision. The genes linked to OCA are expressed at low levels in the neural retina during development and adulthood, but are substantially expressed within the retinal pigment epithelium (RPE). Thus, patient-derived iPSC lines can be a reliable source of human tissue that would otherwise be difficult to come by. 2 There is no available treatment for all forms (8 subtypes) of OCA, which is one of the oldest genetic conditions around. OCA1A and OCA2, caused by mutations in the tyrosinase protein (TYR) and P GENE/OCA2 genes respectively, are the two most common and severe forms of OCA forms in North America.Īffected individuals show different levels, from having none to little pigmentation, which increases their risk for skin cancers and negatively affects their visual acuity. Using patient-derived induced pluripotent stem cells (iPSCs), researchers from the National Eye Institute (NEI) generated a “disease in a dish” model to investigate how defects in the eye’s pigmentation might affect the structure and functionality of the RPE. ![]() The first ever human-derived stem cell model for studying oculocutaneous albinism (OCA) type 1 and 2 has been developed - and this breakthrough paves the way toward more studies to develop potential therapeutics to treat the condition.
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![]() After that, 2B finds a village of robot pacifists. They’re rutting, fighting, even rocking a ramshackle cradle to try and sooth an imaginary baby to sleep, all before they start begging the androids not to kill them. ![]() When you find them, the clanky little cylinders with their glowing eyes are pantomiming humanity at its biological basic. After she and 9S are reunited, they go into a desert where she has to ferret out an enclave of robots who “don’t feel anything,” at least according to YoRHa, the organisation running this android military operation. The permanence of death and its implications on life sit at the heart of Automata’s obsession with classical existentialist philosophy, something it wears on its sleeve even beyond 2B’s Hamlet-sourced name. It’s stopping at the same coffee shop every day and not learning the barista’s name. For them, death just stops meaning anything. There’s no miracle to observe, just a job to do because there’s nothing that special about the fact that they were conscious, then not, then conscious again. Her experience is different - more painful, more tedious given the discomfort of her circumstances - but ultimately the same as 9S’. At the same time, her tone is knowingly formal she’s clearly done this dance before. ![]() When she meets him again, she’s flustered and awkward, not sure how to behave after realising he doesn’t remember the very real intimacy they shared when self-destructing. So he doesn’t remember fighting a couple of building-sized robots with buzzsaw arms? What’s one more death if he is, for the most part, fine?īut 2B is disturbed by the loss of 9S’ waking time. When she meets him later in the android base orbiting a desiccated earth, she still seems rattled even though 9S is walking, talking, and ready to rejoin the fight. While she’s more than willing to blow herself up to off a couple of red-eyed robots at the beginning of Automata, she seems disturbed by the fact that her companion, 9S, has to explode along with her, only his death comes before his most recent memories can be uploaded. The banality of endless resurrection does at least seem to be traumatic for 2B when it’s occasionally disrupted. And when dying is part of your daily routine, what’s one more death? At the end of Automata we get a concise, surprising answer: One more death might be the only thing that matters, in 2B’s life and in the game. She has a black box, a record of her experiences, that will be uploaded back to the android home base so she can slide into a brand new body and keep on going. She’s ready and willing to blow herself up to see the job done because she’s done it before. For Nier: Automata’s fetish-maid-android-samurai, death is just another occupational hazard of waging an endless war on bulbous robots that stole Earth from a seemingly exiled human race. Jitsi Meet started out as a sample conferencing application using Jitsi Videobridge. Instructions on how to build it can be found here. Jitsi Meet is also available as a React Native app for Android and iOS. The service is maintained by the Jitsi team The Jitsi Meet architecture allows you to deploy your own version, includingĪll server components, and in that case your security guarantees will be roughlyĮquivalent to these of a direct one-to-one WebRTC call. Network but decrypted on the machine that hosts the bridge. The simplest integration available out there allows you to. As a matter of fact, unless you consistently vocallyĬompare DTLS fingerprints with your peers, the same goes for one-to-one calls.Īs a result when using a Jitsi Meet instance, your stream is encrypted on the Jitsi as a Service Worlds easiest way to add meetings to your apps. ![]() WebRTC today does not provide a way of conducting multiparty conversations withĮnd-to-end encryption. Jitsi Meet provides a very flexible way of embedding it in external applications by using the Jitsi Meet API. If you are looking to contribute to Jitsi Meet, first of all, thank you! Please The app should be running at Contributing ![]() ![]() On Debian/Ubuntu systems, the required packages can be installed with: You can get our mobile versions from here: You can download source archives (produced by make source-package): For Debian-based systems, we recommend following the quick-install document, which uses the package system.įor other systems, or if you wish to install all components manually, see the detailed manual installation instructions. Installing Jitsi Meet is quite a simple experience. This section is about installing the Jitsi Meet suite on your server and hosting your own conferencing service. You just point your browser to the URL of your deployment. On the client side, no installation is necessary. It also supports shared document editing with Etherpad. It allows users to stream their desktop or only some windows. Jitsi Meet allows for very efficient collaboration. The Jitsi Meet client runs in your browser, without the need for installing anything on your computer. You can see Jitsi Meet in action here at the session #482 of the VoIP Users Conference. Jitsi Meet is an open-source (Apache) WebRTC JavaScript application that uses Jitsi Videobridge to provide high quality, secure and scalable video conferences. Get started with Simwood today and receive an introductory credit of £2 / €2 / $3 to evaluate our termination services.Jitsi Meet - Secure, Simple and Scalable Video Conferences Posted by: Simwood // Intelligent Solutions // ApPost navigation ← COVID-19 impact on UK & USA voice traffic Let’s be honest about value! → Thanks Jitsi team, thanks Sandro, and thanks to all those who make our community awesome. ![]() We talked more about this in “ Building scalable video conferencing“. Instead we have broken out the various components in order to understand and scale it properly as well as, you know, add some value. Or they can update the community image so selflessly offered, and one might think learn a lesson or two in give and take!Īnyway, rant aside, whilst the Docker image is great for running a local meeting or two, we don’t use it. I include here a name who really should know better as the patron of open source projects! Well, they’ll all now need to invent Linux and Docker, then single-handedly with no help whatsoever from anyone, fix it. Some have credited its open source origins which is right and proper, others shamelessly claimed to have “created it”. Now, we know that Simwood Meet has inspired a number of people (we’re counting 12 in our direct network subsequent) to go out and spin up their own. Therein lies the beauty of open source and the community around it people. The official Jitsi Meet demo is patched, the docker image is patched, and Simwood Meet is of course patched, and were before Sandro broke this issue publicly. He’s nice like that and our security and bug bounty had nothing to do with it □ Responsibly, it was reported to the awesome Jitsi team who patched the community Docker image, and Sandro got in touch with us last week to give us a heads up before posting his blog. Our old friend Sandro Gauci (Sipvicious author and all round SIP security guru) has written up an issue with the XMPP component of Jitsi Meet. Today, as fewer and fewer photographers are working in darkrooms, gelatin silver printing is quickly becoming an antiquated, historic process. Color photography was considered a commercial medium, not suited to serious artistic expression. ![]() Until the 1970s, art photographers used this process almost exclusively to create high-quality black and white prints. Properly exposed gelatin silver prints are quite stable if exhibited under controlled light conditions. Digital Vintage Food Illustration Gelatin Deserts & Snacks Clip Art - Print at Home Decor - INSTANT DOWNLOAD. It is not only the superior quality of the prints produced whether they be silver gelatin, c-type, or archival pigment prints but also Metro. We can also offer B&W hand printing from negatives up to 20 x 24 inches. ![]() A negative image is transferred to light-sensitive paper that has four layers: a paper base, a white opaque coating of gelatin and barium sulfate that creates a smooth surface, the gelatin layer that holds the silver grains of the photographic image, and a protective gelatin overcoat. They run from places like Mpix that will print your digital image file onto Ilford resin-coated B&W paper for about 3 for an 8x10 inch print, to pro labs that will print your file onto fiber-based B&W paper for about 50 for an 8x10 inch print, or even more if you want something like selenium toning. Sale Price 30.59 30.59 35.99 Original Price. Our digital B&W papers can be printed up to 108 x 48 inches, either through our in-house Bespoke Service or ordering online. Gift from the Christian Keesee Collection, 2016.041.īefore the advent of digital technology at the end of the twentieth century, the gelatin silver process had been the most commonly used method of making black and white prints since the 1890s. Using Digital Negatives for Contact Printing on Gelatin Silver Chloride Paper. Brett Weston (1911-1993), Mountains and Clouds, New Mexico, c. Avast! Cleanup looks very attractive and the whole program has a nice interface with a simple structure. Also, the program has a built-in scheduler that allows you to configure the start of cleaning after a certain period of time or to specify the exact time of its start. No que toca performance, com esta aplicao voc pode decidir quais programas vo iniciar quando voc ligar seu computador, alm de ajustar. ![]() Your PC isn't getting any younger, but Avast. Avast Cleanup torna possvel se livrar de todo o lixo e arquivos residuais que consomem espao em HDs enquanto esvazia seu histrico de navegao, downloads e cookies de todos os navegadores. It includes a fantastic range of features to boost your PC speed, free up disk space and solve small issues before they become big problems. Avast Cleanup for Windows - Download it from Uptodown for free Windows / Utilities / System / Maintenance / Avast Cleanup Avast Cleanup 11.2.162.0 AVAST Software Dev Onboard 5 2 168.5 k Whip your computer into shape by deleting old files and applications Advertisement Latest version 11.2.162. Avast Cleanup is a next generation tuneup and cleanup for your PC. What’s on your computer right now Let’s make a list. The Avast Q1/2023 Threat Report examines why. It is full offline installer standalone setup of Avast Cleanup Premium v19.1. In addition to cleaning the system, Avast! Cleanup can also optimize it by changing a number of system settings, searching for potentially dangerous applications, and removing insignificant elements from autorun. Avast Software (Trial version) User rating. Emma McGowan Ransomware has been a prominent threat in cybersecurity for more than a decade, but the rates of incidents are showing slight decline. Avast Cleanup Premium Free Download Latest Version. You can't say that this tool will free the disk absolutely from all the "garbage" but after its work you won't face problems like impossibility of launching separate programs or appearance of system errors. Note: This article assumes that the latest version of Avast Cleanup Premium is installed and activated on your PC. Avast! Cleanup can be classified as type two. Avast Cleanup Premium is an optimization tool that scans your PC to identify unnecessary items and performance issues, freeing up disk space and improving the speed of your system. ![]() ![]() Usually such programs are divided into two types: those that remove the maximum amount of "garbage" from the computer, but can negatively affect the stability of the system and those that act less "radically", removing a smaller number of files. In general, there are a lot of such "cleaners" lately. Worldwide (English) Frequently asked questions About us Support. or Continue with Apple Continue with Facebook. Avast! Cleanup is a program for removing temporary files, "tails" left in the system after uninstallation of certain programs, getting rid of "extra" registry keys, browser cache and other useless data that do not perform important functions, but take up disk space or, as in the case of registry keys, slow down the system. Submit button not available until all fields are filled correctly Trouble signing in Create an account. Secil is one of the top European cement brands, and offers great workability. Shelterworks (Faswall’s parent company is bringing the top quality Natural Hydraulic Lime or NHL (Secil brand) to the United States from Portugal. Faswall can Source top quality Secil NHL for Natural Lime Plaster This makes it more accessible to homeowners. Another advantage of natural lime plaster is that plaster application is much more forgiving than stucco application. Lime provides the hardness of cement, but is easier to repair, is more carbon friendly, and is more vapor permeable. Natural lime plaster tends to be more workable than cement plasters, are relatively hard surfaces, and have advantages. It is also cooked in a kiln at higher temperatures than lime. Portland cement is made from limestone, as well, with clay and other mineral additives. Historically, the use of natural lime fell out of favor when portland cement became popular in the 1800s. Natural lime plaster is made from finely ground limestone, a sedimentary rock, that is fired in a kiln. The ingredients in both stucco and plaster are pretty much the same - lime, clay or cement, water, and sand (with many possible additives). Stucco is a rougher texture and plaster is a smoother texture. Generally speaking, most people refer to stucco as a coating for the outside of a building and plaster as a coating for interior walls, although plaster can be used either inside and out. Stucco vs Plaster, what’s the difference? This installation was done by Faswall’s best lime plaster installer and trainer, James Henderson of Henderson Clayworks. Plaster and stucco were used on both interior and exterior surfaces in this home in Kingston, Washington. The skill and labor required for good application is what often makes these finishes more expensive than other finishes. It goes on with care in two to three layers, and is labor intensive. If there is one disadvantage to stucco or plaster, it’s that doing it well can be difficult and is best done by skilled professionals (especially exterior stucco and interior finish coats). Both are fire-resistant and absorb sounds, leading to a more quiet home. They easily take pigments, making them available in a range of colors. Breathable walls help protect your home’s air quality. Perhaps one of the best advantages of plaster and stucco is that they are the best at absorbing and releasing vapor and moisture. Adding lime to a modern mix can increase its workability. Traditional recipes and increasing numbers of modern systems use lime and /or clay instead of cement. The basic composition of both stucco and plaster is water, sand and binder (typically lime, clay and/or cement). The ingredients in these finishes are found in nature, and they have been used as a building finisher for thousands of years. But the advantages of a plaster and/or stucco for walls instead of paint go far beyond appearances. Many people love plasters and stucco as sustainable building finishes because they look nice. Beyond Beauty: Plaster and Stucco are Natural Winners for Sustainable Walls: Use the color wheel to pick the perfect hue for your celebration, or even upload a picture and the colors will match anything from your outdoor furniture to holiday decorations to your outfit of the night. The bulbs were probably in the most danger during installation when we clinked several on concrete with no damage-an action that would’ve certainly shattered a regular glass bulb.īulb Type: Edison-style LED | Number of Bulbs: 15 | Cord Length: 48 feet | Wattage: 13.5 | Power Source: Plug-inĬustomize the color of your lights through your smartphone with ease with these smart outdoor string lights with Govee. The apparent durability went beyond looks we had no blown bulbs in our two-week testing period despite occasional heavy winds. You can also purchase a separate dimmer from the brand to further customize the light output.ĭuring testing, these lights withstood storms and installation. Opting for multiple sets is a great way to offset the brightness issue, giving you the same warm look with a bit more illumination. Each 48-foot-long set gives you 15 bulbs (spaced out appropriately), and you can connect up to 12 strands to cover more space. One factor to note is these bulbs are a bit dimmer than the others on this list, but we found this appealing. What sets them apart is their appearance, which will transform your patio or backyard into a cozy space perfect for outdoor dinner parties and other gatherings. With shatterproof plastic bulbs and weatherproof construction, these commercial-grade lights are just as practical as your standard set. If you're looking to add more ambiance to your outdoor space, check out SUNTHIN's LED Outdoor String Lights that we tested in our own backyard. We appreciate the "moody lighting" these lights emit, and although they weren't bright enough to read under, we think that they are great for decor or entertaining purposes.īulb Type: Edison-style LED | Number of Bulbs: 12 | Cord Length: 27 feet | Wattage: 1 per bulb | Power Source: Solar In fact, the solar panel has a versatile design and can either be clipped to a fence or balcony, or staked in the ground. We love that these string lights don't require any electricity, so you can place them just about anywhere. Although you can't connect multiple strands, they are available in a longer, 48-foot strand. Plus, they are backed by a full 2-year warranty and have a 1,000-charge lifespan (around 2.5 years according to the manufacturer). In fact, they held up well during our lab testing, even when we froze, poured water, or dropped a golf ball on the solar panel. ![]() The 17 vintage-style, Edison bulbs are as practical as they are pretty, and are made of shatterproof plastic. These string lights are one of the priciest picks on our list, but given that LED bulbs use less electricity, are impact-resistant, and can be left outside year-round, we think they are well worth the investment.īulb Type: LED | Number of Bulbs: 12 | Cord Length: 24 | Wattage: Not listed | Power Source: Plug-inĪfter testing dozens of solar lights, these are our favorite. ![]() ![]() Once hung, they had a lovely drape effect and exceptional light quality-bright enough to illuminate the space while still providing just the right ambiance for watching a movie on an outdoor screen. We also found that the lights were heavier than expected, with the setup process requiring more than one person. ![]() On a particularly sunny evening after a nasty week of rain and wind, we them in again. The lights weren’t under a cover so they got the full effect of whatever Mother Nature chose to throw at them. You can link up to 750 feet of these lights to one outlet, giving you enough length to decorate a large outdoor space.ĭuring testing, we left these lights up in one of the rainiest, windiest springs we’ve had in the Pacific Northwest. They're also impact-resistant, and UL listed for permanent outdoor installation, so there's no need to take them down in the winter. The strands are available in three lengths-12, 24, and 48 feet-and strung with LED bulbs, which use less electricity than standard bulbs and last a lifetime. In short, they are the perfect outdoor lights if you want something you can install once and leave up all year long. These features make the Pottery Barn LED String Lights our top pick that we tested-and it doesn't hurt that they're beautiful, drape nicely, and even look stylish when they're not on. LED lights come in many varieties, and they are popular for many reasons: their longer life span, efficient operation, and cool-to-the-touch exterior. The Spruce Home Improvement Review Board. ![]() After a mishap regarding Lag unwittingly firing Gauche's weapon, the shindanjuu, Gauche takes the boy to a cave to rest for the night. Lag has just lost his mother, who has been taken to Akatsuki, Amberground's capital, and the boy is to be delivered to his aunt's residence in Cambel Litus.Īlong the way, the Letter Bee tells the boy briefly about his job and the gaichuu he has to repel. However, he was surprised to find his letter to be a little boy named Lag Seeing. The story begins with 18 year old Gauche Suede, a Letter Bee, arriving to pick up his latest package. ![]() Including to figure out why Gauche is missing. Lag yearns to find his long lost mother, and discover why she abandoned him, if she did. On route, he meets the strange, powerful girl like creature Niche, who becomes his "dingo", a Letter Bee's travelling companion. When he becomes a teenager, he makes the trip to the capital to take the examination to become a trainee Letter Bee. His affection and admiration for Gauche give Lag the ambition to become a Letter Bee himself, carrying mail through the dangerous wasteland between towns on his world. Apparently abandoned by his mother, orphaned Lag Seeing is taken as a "letter" by a "Letter Bee" name Gauche Suede to a town where his aunt raises him. The English version aired on Decemto January 19, 2012. The series aired in Japan on Octoto March 27, 2010. The series was made at the Studio Pierrot Studio in Japan, while it was broadcast on TV Tokyo. The anime series was directed by Akira Iwanaga, while the music was done by Kunihiko Ryo. Tegami Bachi (テガミバチ) is a Japanese anime series created, written and illustrated by Hiroyuki Asada. ![]() But once they’ve overcome any initial caution, then most species of garden bird will regularly return to a window feeder. Yes, they will, though it can take them longer to initially do so compared to bird feeders right out in a garden. Other ways of achieving the same effect are to draw thin lines on the glass with a marker pen about 5cm apart (doesn’t matter which side of the glass), or hang lines of string from the top of the glass the same distance apart. Vertical blinds are ideal as they can be adjusted to allow for enough space for the birds to be observed, but at the same time create a visual barrier which they won’t attempt to fly through. ![]() The best way to do this is by creating vertical lines, which birds see as a barrier and therefore don’t attempt to fly through. One important consideration if using this window bird feeder hook, is to take steps to minimise the risk of birds flying into the glass (this also applies to feeders used in a garden but close to windows). And of course, if more than one bird feeder window hook is used, then more than one type of food can be put out which in turn will attract a greater variety of garden bird species such as Great tit, Coal tit and Siskin. This allows for most types of hanging feeder to be used, such as peanuts, sunflower hearts, seed mixes, suet products or live mealworms. The window hook fixes to the glass using two suction pads, which can take a surprising weight of up to 1.5kg. This then means that birds can be observed feeding very close up. ![]() Our bird feeder window hook is a simple but effective device which allows hanging bird feeders to be positioned right against windows. ![]() Slow, controlled movements that work through your entire range of motion are helpful for increasing flexibility. Use dynamic stretching before your workout and do static stretching after your workout.
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